Safe and efficacious use of recombinant human erythropoietin in malignancy
نویسندگان
چکیده
منابع مشابه
Safe and efficacious use of recombinant human erythropoietin in malignancy.
Recombinant human erythropoietic proteins (rhEpo) can be used in anaemic patients with malignancy receiving chemotherapy to reduce transfusion requirements and improve quality of life. It is highly efficacious when used with appropriate intravenous (iv) iron supplementation to combat functional iron deficiency. There is no indication that rhEpo improves either survival or the outcome of treatme...
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Objective: To evaluate the effect of NIPRD-AM1 on CYP3A4 in order to generate clinically significant data for its safe and efficacious use. Materials and Methods: NIPRD-AM1 is a phytomedicine developed from aqueous root extracts of Nauclea latifolia Smith (Rubiaceae) for the treatment of uncomplicated malaria. The effect of NIPRD-AM1 on CYP3A4 was measured with and without the addition of NIPRD...
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Erythropoietin is an essential growth and viability factor to erythroid progenitors of bone marrow, regulating erythrocyte production and adapting it to the physiological needs for oxygen. Human EPO obtained through recombinant DNA (EPO-hr) technology has enabled its wide therapeutic use. Clinical experience has shown that this molecule is capable of modifying anemia associated to chronic renal...
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Recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. In clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (Epo) increase CFU-E and diminish the number of granulocytes formed per culture plate. Fetal progenitors are more sensitive to these effects of Epo than progenitors from adults. We administered doses 50, 100, 200 IU/...
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INTRODUCTION Recombinant human erythropoietin is used primarily to treat anemia. There is evidence of its neuroprotective capacity from preclinical studies in Parkinson's disease and other neurodegenerative diseases. Recombinant human erythropoietin produced in Cuba (ior-EPOCIM) is registered and approved for use in humans in Cuba and in a number of other countries. OBJECTIVE Assess safety an...
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ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2007
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.7-6-617